Title : Structures of G protein-coupled receptors reveal new opportunities for drug discovery.

Pub. Date : 2015 Nov

PMID : 26303408






1 Functional Relationships(s)
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1 X-ray structures of G protein-coupled receptors (GPCRs) have now been reported for more than 60 ligands and 20 receptors, including examples from GPCR classes A, B, C and F. The new structures show previously unobtainable details of interactions between GPCRs and ligands, including the roles of lipophilic regions and water molecules as key drivers of binding. Water vomeronasal 1 receptor 17 pseudogene Homo sapiens