Title : The Akt/mTOR/p70S6K pathway is activated in IgA nephropathy and rapamycin may represent a viable treatment option.

Pub. Date : 2015 Dec

PMID : 26297427






2 Functional Relationships(s)
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1 Our results showed that p70S6K, S6 and Akt phosphorylation were significantly upregulated in IgAN rats, and rapamycin effectively inhibited p70S6K and S6 phosphorylation. Sirolimus ribosomal protein S6 kinase B1 Rattus norvegicus
2 In conclusion, the Akt/mTOR/p70S6K pathway was activated in IgAN, and our findings suggested that rapamycin may represent a viable option for the treatment of IgAN. Sirolimus ribosomal protein S6 kinase B1 Rattus norvegicus