Title : Low-dose arsenic-mediated metabolic shift is associated with activation of Polo-like kinase 1 (Plk1).

Pub. Date : 2015

PMID : 26292025






2 Functional Relationships(s)
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1 It was recently shown that low-dose arsenic leads to a metabolic shift from mitochondrial respiration to aerobic glycolysis via inactivation of tumor suppressor p53 and activation of NF-kappaB. Arsenic tumor protein p53 Homo sapiens
2 However, how inactivation of p53, activation of NF-kappaB, and metabolic change are coordinated in response to low-dose arsenic exposure is still not completely understood. Arsenic tumor protein p53 Homo sapiens