Title : SS-31 attenuates TNF-α induced cytokine release from C2C12 myotubes.

Pub. Date : 2015 Dec

PMID : 26291279






3 Functional Relationships(s)
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1 An increase was also seen in superoxide in response to treatment with TNF-alpha, which was localised to the mitochondria and this was also associated with activation of NF-kappaB. Superoxides tumor necrosis factor Homo sapiens
2 The changes in superoxide, activation of NF-kB and release of myokines were attenuated following pre-treatment with SS-31 peptide indicating that the ability of TNF-alpha to induce myokine release may be mediated through mitochondrial superoxide, which is, at least in part, associated with activation of the redox sensitive transcription factor NF-kB. Superoxides tumor necrosis factor Homo sapiens
3 The changes in superoxide, activation of NF-kB and release of myokines were attenuated following pre-treatment with SS-31 peptide indicating that the ability of TNF-alpha to induce myokine release may be mediated through mitochondrial superoxide, which is, at least in part, associated with activation of the redox sensitive transcription factor NF-kB. Superoxides tumor necrosis factor Homo sapiens