Pub. Date : 2015 Aug 19
PMID : 26290227
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | UNLABELLED: The derivation of somatic motoneurons (MNs) from ES cells (ESCs) after exposure to sonic hedgehog (SHH) and retinoic acid (RA) is one of the best defined, directed differentiation strategies to specify fate in pluripotent lineages. | Tretinoin | sonic hedgehog signaling molecule | Homo sapiens |
| 2 | UNLABELLED: The derivation of somatic motoneurons (MNs) from ES cells (ESCs) after exposure to sonic hedgehog (SHH) and retinoic acid (RA) is one of the best defined, directed differentiation strategies to specify fate in pluripotent lineages. | Tretinoin | sonic hedgehog signaling molecule | Homo sapiens |
| 3 | Our data demonstrate that RA-mediated suppression of GLI3 is sufficient to generate MNs in an SHH-independent manner and that temporal changes in exposure to patterning factors such as RA affect chromatin state and competency of hESC-derived lineages to adopt specific neuronal fates. | Tretinoin | sonic hedgehog signaling molecule | Homo sapiens |
| 4 | We show that early exposure to retinoic acid modulates the chromatin state of cells to be permissive for motoneuron generation and directly suppresses the induction of GLI3, a negative regulator of SHH signaling. | Tretinoin | sonic hedgehog signaling molecule | Homo sapiens |
| 5 | Therefore, our data point to a novel mechanism by which retinoic acid exposure can bypass the requirement for extrinsic SHH treatment during motoneuron induction. | Tretinoin | sonic hedgehog signaling molecule | Homo sapiens |