Title : Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.

Pub. Date : 2015 Sep

PMID : 26280532






2 Functional Relationships(s)
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1 Using mouse cells containing targeted mutant alleles of Mre11 (Mre11a) and/or Ku70 (Xrcc6), together with pharmacologic kinase inhibition, we demonstrate that ATM can be activated by DSBs in the absence of MRN. dsbs X-ray repair complementing defective repair in Chinese hamster cells 6 Mus musculus
2 Using mouse cells containing targeted mutant alleles of Mre11 (Mre11a) and/or Ku70 (Xrcc6), together with pharmacologic kinase inhibition, we demonstrate that ATM can be activated by DSBs in the absence of MRN. dsbs X-ray repair complementing defective repair in Chinese hamster cells 6 Mus musculus