Title : [Transforming growth factor-β1 induces epithelial-mesenchymal transition in A549 cells by up-regulating expression of calpain].

Pub. Date : 2015 Mar

PMID : 26269309






4 Functional Relationships(s)
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1 While, after calpain inhibitor PD150606 was added, the protein and mRNA expression of Calpain-1 and alpha-SMA was markedly decreased and the protein and mRNA expression of E-cad was significantly increased in the TGF-betal + PD150606 group, but there was no difference between TGF-beta1 + PD150606 group and control group. PD 150606 cadherin 1 Homo sapiens
2 While, after calpain inhibitor PD150606 was added, the protein and mRNA expression of Calpain-1 and alpha-SMA was markedly decreased and the protein and mRNA expression of E-cad was significantly increased in the TGF-betal + PD150606 group, but there was no difference between TGF-beta1 + PD150606 group and control group. PD 150606 cadherin 1 Homo sapiens
3 While, after calpain inhibitor PD150606 was added, the protein and mRNA expression of Calpain-1 and alpha-SMA was markedly decreased and the protein and mRNA expression of E-cad was significantly increased in the TGF-betal + PD150606 group, but there was no difference between TGF-beta1 + PD150606 group and control group. PD 150606 cadherin 1 Homo sapiens
4 But with Calpain inhibitor PD150606 alone, the expression of Calpain-1,E-cad and alpha-SMA was no difference with the control group. PD 150606 cadherin 1 Homo sapiens