Title : HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia.

Pub. Date : 2016 Jan

PMID : 26265185

1 Functional Relationships(s)
Compound Name
Protein Name
1 STAT1 protein levels were not affected by AUY922 treatment, but phospho-STAT1 (Tyr-701) levels rapidly became undetectable, consistent with a block in signaling downstream of TYK2. Tyrosine signal transducer and activator of transcription 1 Homo sapiens