Pub. Date : 2015 Dec
PMID : 26257239
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sorafenib enriches epithelial cell adhesion molecule-positive tumor initiating cells and exacerbates a subtype of hepatocellular carcinoma through TSC2-AKT cascade. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | The TSC2-AKT cascade mediates this sorafenib resistance. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In response to sorafenib treatment, formation of the TSC1/2 complex is enhanced, causing increased phosphorylation of AKT, which contributes to up-regulation of "stemness"-related genes in epithelial cell adhesion molecule-positive cells and enhancement of tumorigenicity. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |