Title : Contribution of nitric oxide-dependent guanylate cyclase and reactive oxygen species signaling pathways to desensitization of μ-opioid receptors in the rat locus coeruleus.

Pub. Date : 2015 Dec

PMID : 26254861






1 Functional Relationships(s)
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1 ME (10 muM)-induced desensitization was blocked by the neuronal NO synthase inhibitor 7-NI (100 muM) and restored by the PKG activator 8-Br-cGMP (100-300 muM). 8-bromoguanosino-3',5'-cyclic monophosphorothioate latexin Homo sapiens