Title : Contribution of nitric oxide-dependent guanylate cyclase and reactive oxygen species signaling pathways to desensitization of μ-opioid receptors in the rat locus coeruleus.

Pub. Date : 2015 Dec

PMID : 26254861






2 Functional Relationships(s)
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1 ME (3 muM)-induced desensitization was enhanced by a NO donor (DEA/NO 100 muM), two soluble guanylate cyclase (sGC) activators (A 350619 30 muM and BAY 418543 1 muM) or a cGMP-dependent protein kinase (PKG) activator (8-pCPT-cGMP 30 muM). dea latexin Homo sapiens
2 DEA/NO-induced enhancement was blocked by the sGC inhibitor NS 2028 (10 muM). dea latexin Homo sapiens