Pub. Date : 2015 Nov
PMID : 26250606
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | GSK2126458 decreased phospho-AKT while increasing phospho-ERK and AZD6244 decreased phospho-ERK efficiently while increasing phospho-AKT. | AZD 6244 | AKT serine/threonine kinase 1 | Homo sapiens |
2 | The combination of GSK2126458 and AZD6244 decreased both phospho-AKT and phospho-ERK effectively in vitro and in vivo. | AZD 6244 | AKT serine/threonine kinase 1 | Homo sapiens |
3 | CONCLUSIONS: The combination of GSK2126458 and AZD6244 blocks both the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways simultaneously and is an effective strategy for the treatment of CRPCs. | AZD 6244 | AKT serine/threonine kinase 1 | Homo sapiens |