Title : Addition of niclosamide to palladium(II) saccharinate complex of terpyridine results in enhanced cytotoxic activity inducing apoptosis on cancer stem cells of breast cancer.

Pub. Date : 2015 Sep 1

PMID : 26234907






1 Functional Relationships(s)
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1 Our study demonstrated that the combination of niclosamide (1.5 muM) and Pd(II) complex (12.5, 25 and 50 muM) at 48 h has enhanced cytotoxic activity resulted from the induction of apoptosis (indicated by the presence of pyknotic nuclei, increments in M30 and over expression of proapoptotic genes of TNFRSF10A and FAS). Niclosamide TNF receptor superfamily member 10a Homo sapiens