Pub. Date : 2015
PMID : 26233912
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of Retinoic Acid-Metabolizing Cytochrome P450s, CYP26, in Inflammation and Cancer. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 2 | Concentrations of atRA are tightly regulated in tissues, predominantly by the availability of retinol, synthesis of atRA by ALDH1A enzymes and metabolism and clearance of atRA by CYP26 enzymes. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 3 | Inhibition of the CYP26 enzymes to increase atRA concentrations and combat therapy resistance has been pursued as a drug target in these cancers. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |