Title : Superoxide induces protein oxidation in plasma and TNF-α elevation in macrophage culture: Insights into mechanisms of neurotoxicity following doxorubicin chemotherapy.

Pub. Date : 2015 Oct 28

PMID : 26225838






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1 Superoxide induces protein oxidation in plasma and TNF-alpha elevation in macrophage culture: Insights into mechanisms of neurotoxicity following doxorubicin chemotherapy. Doxorubicin tumor necrosis factor Homo sapiens
2 Our group previously demonstrated that Dox, which does not cross the BBB, induced oxidative damage to plasma proteins leading to TNF-alpha elevation in the periphery and, subsequently, in brain following cancer chemotherapy. Doxorubicin tumor necrosis factor Homo sapiens
3 The current study tested the notion that O2(-) is involved and likely responsible for Dox-induced plasma protein oxidation and TNF-alpha release. Doxorubicin tumor necrosis factor Homo sapiens
4 These findings, together with our prior results, provide strong evidence that O2(-) and its resulting reactive species are critically involved in Dox-induced plasma protein oxidation and TNF-alpha release. Doxorubicin tumor necrosis factor Homo sapiens