Pub. Date : 2015 Oct 28
PMID : 26225838
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Superoxide induces protein oxidation in plasma and TNF-alpha elevation in macrophage culture: Insights into mechanisms of neurotoxicity following doxorubicin chemotherapy. | Doxorubicin | tumor necrosis factor | Homo sapiens |
2 | Our group previously demonstrated that Dox, which does not cross the BBB, induced oxidative damage to plasma proteins leading to TNF-alpha elevation in the periphery and, subsequently, in brain following cancer chemotherapy. | Doxorubicin | tumor necrosis factor | Homo sapiens |
3 | The current study tested the notion that O2(-) is involved and likely responsible for Dox-induced plasma protein oxidation and TNF-alpha release. | Doxorubicin | tumor necrosis factor | Homo sapiens |
4 | These findings, together with our prior results, provide strong evidence that O2(-) and its resulting reactive species are critically involved in Dox-induced plasma protein oxidation and TNF-alpha release. | Doxorubicin | tumor necrosis factor | Homo sapiens |