Pub. Date : 2015
PMID : 26221255
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Honokiol induces cell cycle arrest and apoptosis via p53 activation in H4 human neuroglioma cells. | honokiol | tumor protein p53 | Homo sapiens |
| 2 | OBJECTIVE: To investigate the signal pathway of honokiol-induced apoptosis in H4 human neuroglioma cells and to evaluate whether p53 signaling and cell cycle arrest were involved in honokiol-treated H4 human neuroglioma cells. | honokiol | tumor protein p53 | Homo sapiens |
| 3 | Moreover, p53, p21 and Bax/Bcl-2 were significantly upregulated by honokiol treatment. | honokiol | tumor protein p53 | Homo sapiens |
| 4 | CONCLUSIONS: These results confirmed that honokiol could induce apoptosis in human neuroglioma cells, the underlying molecular mechanisms, at least partially, through activation p53 signaling and induction of cell cycle arrest. | honokiol | tumor protein p53 | Homo sapiens |