Title : Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer.

Pub. Date : 2016 Apr 28

PMID : 26212011






1 Functional Relationships(s)
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1 We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt. pi(4,5)p2 AKT serine/threonine kinase 1 Homo sapiens