Pub. Date : 2015 Oct
PMID : 26206949
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sorafenib Action in Hepatitis B Virus X-Activated Oncogenic Androgen Pathway in Liver through SHP-1. | Sorafenib | nuclear receptor subfamily 0 group B member 2 | Homo sapiens |
| 2 | Sorafenib markedly inhibited the HBx-enhanced AR activity through activating the SHP-1 phosphatase, which antagonized the activation of Akt/GSK3beta and c-Src by HBx. | Sorafenib | nuclear receptor subfamily 0 group B member 2 | Homo sapiens |
| 3 | Moreover, SHP-1 protein level was much higher in the liver than in testis, which enabled sorafenib to inhibit aberrant AR activity in the HBx-expressing liver, while not affecting the physiological AR function in normal liver or testis. | Sorafenib | nuclear receptor subfamily 0 group B member 2 | Homo sapiens |