Title : Vitamin D3 enhances the tumouricidal effects of 5-Fluorouracil through multipathway mechanisms in azoxymethane rat model of colon cancer.

Pub. Date : 2015 Jul 25

PMID : 26205949






1 Functional Relationships(s)
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1 Mechanistically, vitamin D3/5-FU co-therapy significantly decreased the expression of Wnt, beta-catenin, iNOS, COX-2 and HSP-90 and significantly increased the expression of DKK-1, TGF-beta1, TGF-betaR2, smad4 (P < 0.05), in comparison with their corresponding monotherapy groups. Cholecalciferol dickkopf WNT signaling pathway inhibitor 1 Rattus norvegicus