Title : Role of the nucleotide-binding domain-like receptor protein 3 inflammasome in acute kidney injury.

Pub. Date : 2015 Oct

PMID : 26198480






1 Functional Relationships(s)
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1 Genetic deletion of NLRP3 reversed the CLP-induced reduction in blood pressure and increases in serum creatinine level and neutrophil infiltration, and attenuated the CLP-induced upregulation of apoptosis-associated speck-like protein, caspase-1 expression and activity, and the secretion of IL-1beta and IL-18, similarly to the effects of caspase-1 inhibition. Creatinine NLR family pyrin domain containing 3 Homo sapiens