Title : Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction.

Pub. Date : 2015 Sep

PMID : 26196303






2 Functional Relationships(s)
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1 AMPK activators salicylate and AICAR prevented ROS-induced mitochondrial fission by enhancing dynamin-related protein 1 (Drp1) phosphorylation (Ser 637) and thereby attenuated IRE-1alpha and PERK phosphorylation, but their actions were blocked by knockdown of AMPK. Salicylates protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
2 AMPK activators salicylate and AICAR prevented ROS-induced mitochondrial fission by enhancing dynamin-related protein 1 (Drp1) phosphorylation (Ser 637) and thereby attenuated IRE-1alpha and PERK phosphorylation, but their actions were blocked by knockdown of AMPK. Salicylates protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus