Title : Activation of CB2 receptor is required for the therapeutic effect of ABHD6 inhibition in experimental autoimmune encephalomyelitis.

Pub. Date : 2015 Dec

PMID : 26189763






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Alpha/beta-hydrolase domain 6 (ABHD6) is a novel 2-arachidonoylglycerol (2-AG) hydrolytic enzyme, that can fine-tune the endocannabinoid signaling in the central nervous system. glyceryl 2-arachidonate abhydrolase domain containing 6 Mus musculus
2 Alpha/beta-hydrolase domain 6 (ABHD6) is a novel 2-arachidonoylglycerol (2-AG) hydrolytic enzyme, that can fine-tune the endocannabinoid signaling in the central nervous system. glyceryl 2-arachidonate abhydrolase domain containing 6 Mus musculus
3 Alpha/beta-hydrolase domain 6 (ABHD6) is a novel 2-arachidonoylglycerol (2-AG) hydrolytic enzyme, that can fine-tune the endocannabinoid signaling in the central nervous system. glyceryl 2-arachidonate abhydrolase domain containing 6 Mus musculus
4 Alpha/beta-hydrolase domain 6 (ABHD6) is a novel 2-arachidonoylglycerol (2-AG) hydrolytic enzyme, that can fine-tune the endocannabinoid signaling in the central nervous system. glyceryl 2-arachidonate abhydrolase domain containing 6 Mus musculus
5 Given the increased expression of ABHD6 in microglia/macrophages, but not in T cells, we speculated that inhibition of ABHD6 might enhance 2-AG signaling particularly in microglia/macrophages to exert anti-inflammatory effects via activation of CB2 receptors. glyceryl 2-arachidonate abhydrolase domain containing 6 Mus musculus
6 Given the increased expression of ABHD6 in microglia/macrophages, but not in T cells, we speculated that inhibition of ABHD6 might enhance 2-AG signaling particularly in microglia/macrophages to exert anti-inflammatory effects via activation of CB2 receptors. glyceryl 2-arachidonate abhydrolase domain containing 6 Mus musculus