Title : Post-translational regulation of PTEN catalytic function and protein stability in the hibernating 13-lined ground squirrel.

Pub. Date : 2015 Nov

PMID : 26189697






1 Functional Relationships(s)
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1 RESULTS: During torpor, the ratio of non-phosphorylated PTEN (S380/T382/T383) was significantly elevated by 1.4-fold during late torpor compared with euthermic controls; this was coupled with an increase in substrate affinity for PIP3 (by 56%) in late torpor. PIP3 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Ictidomys tridecemlineatus