Pub. Date : 2015 Sep
PMID : 26188848
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The potential of clofarabine in MLL-rearranged infant acute lymphoblastic leukaemia. | Clofarabine | lysine methyltransferase 2A | Homo sapiens |
| 2 | Here we explored the in vitro potential of the novel nucleoside analogue clofarabine for MLL-rearranged infant ALL. | Clofarabine | lysine methyltransferase 2A | Homo sapiens |
| 3 | Compared with other nucleoside analogues, clofarabine effectively targeted primary MLL-rearranged infant ALL cells at the lowest concentrations, with median LC50 values of ~25 nM. | Clofarabine | lysine methyltransferase 2A | Homo sapiens |
| 4 | Furthermore, at concentrations of 5-10nM clofarabine induced demethylation of the promoter region of the tumour suppressor gene FHIT (Fragile Histidine Triad), a gene typically hypermethylated in MLL-rearranged ALL. | Clofarabine | lysine methyltransferase 2A | Homo sapiens |
| 5 | We conclude that clofarabine is an interesting candidate for further studies in MLL-rearranged ALL in infants. | Clofarabine | lysine methyltransferase 2A | Homo sapiens |