Pub. Date : 2015 Dec
PMID : 26174951
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization. | Resveratrol | vascular endothelial growth factor A | Homo sapiens |
| 2 | Western blot and ELISA assay showed that RSV inhibited hypoxia-inducible factor (HIF)-1alpha accumulation and VEGF secretion induced by cobalt chloride (CoCl2) through SIRT1 in human retinal pigment epithelial (hRPE) cells. | Resveratrol | vascular endothelial growth factor A | Homo sapiens |
| 3 | Furthermore, RSV down-regulated VEGFR2 phosphorylation and activation induced by VEGF in endothelial cells via SIRT1. | Resveratrol | vascular endothelial growth factor A | Homo sapiens |
| 4 | Thus, the inhibitory effect of RSV on the HIF-1alpha/VEGF/VEGFR2 signaling axis is mediated, at least in part, through SIRT1. | Resveratrol | vascular endothelial growth factor A | Homo sapiens |