Pub. Date : 2015 Jul
PMID : 26171149
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of human cervical carcinoma (HeLa) cells with SB203580, an inhibitor of p38 MAPK, enhanced basal USP22 promoter activity and mRNA abundance. | SB 203580 | ubiquitin specific peptidase 22 | Homo sapiens |
| 2 | Transfection of MAPK kinase 6 (MKK6), an upstream activator of p38 MAPK, resulted in a 40% decrease in USP22 mRNA, while the dominant negative MKK6 increased the transcription level of the USP22, similar to SB203580. | SB 203580 | ubiquitin specific peptidase 22 | Homo sapiens |
| 3 | Transfection of MAPK kinase 6 (MKK6), an upstream activator of p38 MAPK, resulted in a 40% decrease in USP22 mRNA, while the dominant negative MKK6 increased the transcription level of the USP22, similar to SB203580. | SB 203580 | ubiquitin specific peptidase 22 | Homo sapiens |
| 4 | Dual luciferase report assays showed that mutations of the Sp1 binding site ahead of the transcription start site abolished the promoting effect of the USP22 promoter by SB203580. | SB 203580 | ubiquitin specific peptidase 22 | Homo sapiens |