Title : NKCC1 downregulation induces hyperpolarizing shift of GABA responsiveness at near term fetal stages in rat cultured dorsal root ganglion neurons.

Pub. Date : 2015 Jul 14

PMID : 26169500






3 Functional Relationships(s)
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1 NKCC1 downregulation induces hyperpolarizing shift of GABA responsiveness at near term fetal stages in rat cultured dorsal root ganglion neurons. gamma-Aminobutyric Acid solute carrier family 12 member 2 Rattus norvegicus
2 In embryonic neurons Na-K-2Cl (NKCC1) cotransporters mediate active chloride uptake, thus increasing the intracellular chloride concentration associated with GABA-induced depolarization. gamma-Aminobutyric Acid solute carrier family 12 member 2 Rattus norvegicus
3 At fetal stages near term, oxytocin-induced NKCC1 downregulation has been implicated in the developmental shift from depolarizing to hyperpolarizing GABA action. gamma-Aminobutyric Acid solute carrier family 12 member 2 Rattus norvegicus