Title : Celastrol induces apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway.

Pub. Date : 2015 Sep

PMID : 26165547






1 Functional Relationships(s)
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1 Furthermore, we observed that celastrol upregulated the expression of the pro-apoptotic proteins Bax and cytochrome c and altered the ratio of Bax/Bcl-2, and triggered the mitochondrial apoptotic pathway, resulting in caspase-3 and -9 activation and PARP cleavage. celastrol collagen type XI alpha 2 chain Homo sapiens