Pub. Date : 2015 Aug 5
PMID : 26148435
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Arsenic-induced S phase cell cycle lengthening is associated with ROS generation, p53 signaling and CDC25A expression. | Arsenic | tumor protein p53 | Homo sapiens |
| 2 | Cellular response to arsenic is strongly dependent on p53 functional status. | Arsenic | tumor protein p53 | Homo sapiens |
| 3 | Primarily arresting the cell cycle in G1 or G2/M phases, arsenic treatment also induces an increase in the S-phase time in wild-type p53 cells. | Arsenic | tumor protein p53 | Homo sapiens |
| 4 | In contrast, cells with a non-functional p53 display only a subtle increase in the S phase, indicating arsenic differentially affects the cell cycle depending on p53 status. | Arsenic | tumor protein p53 | Homo sapiens |
| 5 | In contrast, cells with a non-functional p53 display only a subtle increase in the S phase, indicating arsenic differentially affects the cell cycle depending on p53 status. | Arsenic | tumor protein p53 | Homo sapiens |
| 6 | Importantly, it has been reported that arsenic induces reactive oxygen species (ROS), a process counteracted by p53. | Arsenic | tumor protein p53 | Homo sapiens |
| 7 | To evaluate the participation of p53 in the lengthening of the S phase and the connection between the transient cell cycle arrest and oxidative stress, we evaluated the cell response to arsenic in MCF-7 and H1299 cells, and analyzed p53"s role as a transcription factor in regulating genes involved in ROS reduction and S phase transition. | Arsenic | tumor protein p53 | Homo sapiens |
| 8 | Herein, we discovered that arsenic induced an increase in the population of S phase cells that was dependent on the presence and transcriptional activity of p53. | Arsenic | tumor protein p53 | Homo sapiens |
| 9 | Furthermore, for the first time, we demonstrate that arsenic activates p53-dependent transcription of ROS detoxification genes, such as SESN1, and by an indirect mechanism involving ATF3, genes that could be responsible for the S phase cell cycle arrest, such as CDC25A. | Arsenic | tumor protein p53 | Homo sapiens |