Title : Synergistic induction of insulin resistance by endothelin-1 and cAMP in 3T3-L1 adipocytes.

Pub. Date : 2015 Oct

PMID : 26143144






4 Functional Relationships(s)
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1 Insulin-stimulated glucose uptake, phosphorylation of PKB, IRS-1-associated PI3K, and IRS-1 tyrosine phosphorylation were all inhibited by ET-1 and 8-bromo cAMP in a synergistic manner. Tyrosine insulin receptor substrate 1 Homo sapiens
2 In addition, after correction for the loss in IRS-1 protein, the inhibition of insulin-stimulated IRS-1 tyrosine phosphorylation or IRS-1-associated PI3K was mainly caused by cAMP. Tyrosine insulin receptor substrate 1 Homo sapiens
3 In addition, after correction for the loss in IRS-1 protein, the inhibition of insulin-stimulated IRS-1 tyrosine phosphorylation or IRS-1-associated PI3K was mainly caused by cAMP. Tyrosine insulin receptor substrate 1 Homo sapiens
4 In addition, after correction for the loss in IRS-1 protein, the inhibition of insulin-stimulated IRS-1 tyrosine phosphorylation or IRS-1-associated PI3K was mainly caused by cAMP. Tyrosine insulin receptor substrate 1 Homo sapiens