Title : Alpha 7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to 5-fluorouracil.

Pub. Date : 2015 Dec

PMID : 26136123






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We analyzed expression levels of survival and apoptosis-associated proteins (pAkt, Akt, Mcl-1, Bcl-2, Bad, and Bax) altered by 5-FU treatment. Fluorouracil BCL2 associated X, apoptosis regulator Homo sapiens
2 Survival and antiapoptosis signaling (pAkt, Akt, Mcl-1 and Bcl-2) was downregulated, and the proapoptotic proteins (Bad and Bax) were upregulated in 5-FU-treated control cells but expression levels of Bcl-2, Bad, and Bad were not altered in 5-FU-treated A7-nAChR-KD cells. Fluorouracil BCL2 associated X, apoptosis regulator Homo sapiens