Pub. Date : 2015
PMID : 26133709
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Time-Dependent Inhibition of hOAT1 and hOAT3 by Anthraquinones. | Anthraquinones | solute carrier family 22 member 8 | Homo sapiens |
| 2 | We previously showed that anthraquinones (including rhein, emodin, aloe-emodin, chrysophanol and physcion) were inhibitors of human organic anion transporter 1 (hOAT1) and hOAT3, causing transporter-mediated drug-drug interactions in rats. | Anthraquinones | solute carrier family 22 member 8 | Homo sapiens |
| 3 | In this study, the time-dependent inhibition (TDI) of hOAT1 and hOAT3 by anthraquinones was investigated. | Anthraquinones | solute carrier family 22 member 8 | Homo sapiens |
| 4 | In conclusion, our results suggest that some anthraquinones contribute to the TDI of hOAT1 and hOAT3. | Anthraquinones | solute carrier family 22 member 8 | Homo sapiens |
| 5 | An inhibition study without the preincubation procedure may underestimate the inhibitory potential of anthraquinones against hOAT1 and hOAT3. | Anthraquinones | solute carrier family 22 member 8 | Homo sapiens |