Title : Correlation of UGT1A1 and ERCC1 gene polymorphisms with the outcome of combined irinotecan plus cisplatin treatment in recurrent ovarian cancer.

Pub. Date : 2015 Jun 29

PMID : 26125934






3 Functional Relationships(s)
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1 Correlation of UGT1A1 and ERCC1 gene polymorphisms with the outcome of combined irinotecan plus cisplatin treatment in recurrent ovarian cancer. Irinotecan ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
2 The aim of this study was to define the genotypes of UGT1A1 and ERCC1 and to examine their relationship with the efficacy and toxicity of a combination therapy of irinotecan and cisplatin in patients with advanced ovarian cancer. Irinotecan ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
3 Furthermore, the results suggest that ERCC1 WW carriers might obtain a better rate of clinical response from a combined irinotecan and cisplatin regimen than ERCC1 WM+MM carriers. Irinotecan ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens