Title : The hepatic circadian clock regulates the choline kinase α gene through the BMAL1-REV-ERBα axis.

Pub. Date : 2015

PMID : 26125130






1 Functional Relationships(s)
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1 Consistent with the antiphasic phase relationship between Chkalpha and Rev-erbalpha expression, in cotransfection experiments using HepG2 cells we show that RORalpha4-dependent transactivation of this element is repressed by REV-ERBalpha Correspondingly, Rev-erbalpha(-/-)mice displayed higher Chkalpha mRNA levels in liver at ZT 12. rev-erbalpha choline kinase alpha Homo sapiens