Title : RTKN2 Induces NF-KappaB Dependent Resistance to Intrinsic Apoptosis in HEK Cells and Regulates BCL-2 Genes in Human CD4(+) Lymphocytes.

Pub. Date : 2009

PMID : 26124677






2 Functional Relationships(s)
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1 Here we show that stable expression of RTKN2 in HEK cells enhanced survival in response to intrinsic apoptotic agents; 25-hydroxy cholesterol and camptothecin, but not the extrinsic agent, TNFalpha. 25-hydroxycholesterol rhotekin 2 Homo sapiens
2 Consistent with the role of RTKN2 in HEK over-expressing cells, suppression of RTKN2 in primary human CD4(+) T-cells reduced viability and increased sensitivity to 25-OHC. 25-hydroxycholesterol rhotekin 2 Homo sapiens