Title : Changes in hepatic cytosolic glutathione S-transferase enzymes induced by clotrimazole treatment in rats.

Pub. Date : 1989 Nov

PMID : 2612064






3 Functional Relationships(s)
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1 Hepatic glutathione S-transferase activity was determined with five different substrates: 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), p-nitro-benzyl chloride (PNBC), ethacrynic acid (EA) and trans-4-phenyl-3-buten-2-one (TPBO). Dinitrochlorobenzene hematopoietic prostaglandin D synthase Rattus norvegicus
2 Hepatic glutathione S-transferase activity was determined with five different substrates: 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), p-nitro-benzyl chloride (PNBC), ethacrynic acid (EA) and trans-4-phenyl-3-buten-2-one (TPBO). Dinitrochlorobenzene hematopoietic prostaglandin D synthase Rattus norvegicus
3 The largest increases in glutathione S-transferase activity were found with CDNB, DCNB and PNBC (+61%, +50% and +50%, respectively, when expressed per mg of cytosolic protein). Dinitrochlorobenzene hematopoietic prostaglandin D synthase Rattus norvegicus