Title : Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation.

Pub. Date : 2015 Feb 28

PMID : 26120598






1 Functional Relationships(s)
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1 Further investigation into the effects of metformin suggest that the drug directly activates AMPK and dose-dependently suppressed the release of TNF-alpha, IL-6, and MCP-1 by macrophages while enhancing the release of IL-10 in vitro. Metformin C-C motif chemokine ligand 2 Homo sapiens