Title : NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7.

Pub. Date : 2015 Jun 27

PMID : 26116564






2 Functional Relationships(s)
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1 TPA-induced induction of MMP-7 expression was suppressed by AP-1, NF-kappaB, and MAPK (ERK, p38, and JNK) inhibitors, whereas TPA-induced expression of NOX2 and its regulators, p47phox and p67phox, was blocked by p38 and NF-kappaB inhibitors. Tetradecanoylphorbol Acetate neutrophil cytosolic factor 1 Homo sapiens
2 TPA-induced induction of MMP-7 expression was suppressed by AP-1, NF-kappaB, and MAPK (ERK, p38, and JNK) inhibitors, whereas TPA-induced expression of NOX2 and its regulators, p47phox and p67phox, was blocked by p38 and NF-kappaB inhibitors. Tetradecanoylphorbol Acetate neutrophil cytosolic factor 1 Homo sapiens