Title : Blockage of TGFβ-SMAD2 by demethylation-activated miR-148a is involved in caffeic acid-induced inhibition of cancer stem cell-like properties in vitro and in vivo.

Pub. Date : 2015

PMID : 26106521






5 Functional Relationships(s)
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1 Blockage of TGFbeta-SMAD2 by demethylation-activated miR-148a is involved in caffeic acid-induced inhibition of cancer stem cell-like properties in vitro and in vivo. caffeic acid transforming growth factor beta 1 Homo sapiens
2 Here, we found that CaA attenuated the CSCs-like properties by the microRNA-148a (miR-148a)-mediated inhibition of transforming growth factor beta (TGFbeta)-SMAD2 signaling pathway both in vitro and in vivo. caffeic acid transforming growth factor beta 1 Homo sapiens
3 Here, we found that CaA attenuated the CSCs-like properties by the microRNA-148a (miR-148a)-mediated inhibition of transforming growth factor beta (TGFbeta)-SMAD2 signaling pathway both in vitro and in vivo. caffeic acid transforming growth factor beta 1 Homo sapiens
4 Knockdown of miR-148a abolished the CaA-induced inhibition of TGFbeta-SMAD2 signal pathway and the CSCs-like properties. caffeic acid transforming growth factor beta 1 Homo sapiens
5 Our study found a novel mechanism that CaA inhibits the CSCs-like properties via miR-148a-mediated inhibition of TGFbeta-SMAD2 signaling pathway, which may help to identify a new approach for the treatment of human cancers. caffeic acid transforming growth factor beta 1 Homo sapiens