Title : Novel Cancer Therapeutics with Allosteric Modulation of the Mitochondrial C-Raf-DAPK Complex by Raf Inhibitor Combination Therapy.

Pub. Date : 2015 Sep 1

PMID : 26100670






2 Functional Relationships(s)
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1 Combined use of the Raf inhibitors sorafenib and GW5074 had synergistic anticancer effects in vitro and in vivo, but targeted mitochondrial function, rather than the canonical Raf signaling pathway. 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone zinc fingers and homeoboxes 2 Homo sapiens
2 Combined use of the Raf inhibitors sorafenib and GW5074 had synergistic anticancer effects in vitro and in vivo, but targeted mitochondrial function, rather than the canonical Raf signaling pathway. 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone zinc fingers and homeoboxes 2 Homo sapiens