Pub. Date : 2015
PMID : 26097873
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Moreover, we found that cathepsin B enzymatic activity, induced by sorafenib, is dependent on its dephosphorylation via PTEN activation and Akt inactivation. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | In addition, the Akt inhibitor perifosine increased the sensitivity of bladder cancer cells to sorafenib-induced cytotoxicity. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Overall, our results show that apoptotic cell death induced by sorafenib in bladder cancer cells is dependent on cathepsin B activity and involved PTEN and Akt signaling pathways. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | The Akt inhibitor perifosine increased the cytotoxic effects of sorafenib in bladder cancer cells. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |