Title : Microcystin-LR altered mRNA and protein expression of endoplasmic reticulum stress signaling molecules related to hepatic lipid metabolism abnormalities in mice.

Pub. Date : 2015 Jul

PMID : 26093960






2 Functional Relationships(s)
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1 MC-LR exposure at 10 or 20 mug/kg/d also altered mRNA and protein expression of downstream factors and genes of ER stress signaling pathways, including the downregulation of sterol regulatory element binding protein 1c (SREBP-1c) and fatty acid synthase (FASn), and upregulation of acetyl-coenzyme A carboxylase alpha (ACACA) and glycogen synthase kinase 3beta (Gsk-3beta). cyanoginosin LR acetyl-Coenzyme A carboxylase alpha Mus musculus
2 MC-LR exposure at 10 or 20 mug/kg/d also altered mRNA and protein expression of downstream factors and genes of ER stress signaling pathways, including the downregulation of sterol regulatory element binding protein 1c (SREBP-1c) and fatty acid synthase (FASn), and upregulation of acetyl-coenzyme A carboxylase alpha (ACACA) and glycogen synthase kinase 3beta (Gsk-3beta). cyanoginosin LR acetyl-Coenzyme A carboxylase alpha Mus musculus