Title : Role of dihydrotestosterone (DHT) on TGF-β1 signaling pathway in epithelial ovarian cancer cells.

Pub. Date : 2016 Jan

PMID : 26091707






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1 Role of dihydrotestosterone (DHT) on TGF-beta1 signaling pathway in epithelial ovarian cancer cells. Dihydrotestosterone transforming growth factor beta 1 Homo sapiens
2 Role of dihydrotestosterone (DHT) on TGF-beta1 signaling pathway in epithelial ovarian cancer cells. Dihydrotestosterone transforming growth factor beta 1 Homo sapiens
3 The purpose of the present study was to evaluate whether DHT causes changes in the TGF-beta1 pathway that might modify the anti-proliferative effect of the latter. Dihydrotestosterone transforming growth factor beta 1 Homo sapiens
4 Additionally, after treatment of cell lines with DHT, protein levels of TGF-beta1 receptors (TGFBR1-TGFBR2) showed a decrease (p < 0.05) that might cause a potential disorder in TGF-beta1 response, represented by the significant decrease in p21 protein levels in the presence of DHT (p < 0.001). Dihydrotestosterone transforming growth factor beta 1 Homo sapiens
5 Additionally, after treatment of cell lines with DHT, protein levels of TGF-beta1 receptors (TGFBR1-TGFBR2) showed a decrease (p < 0.05) that might cause a potential disorder in TGF-beta1 response, represented by the significant decrease in p21 protein levels in the presence of DHT (p < 0.001). Dihydrotestosterone transforming growth factor beta 1 Homo sapiens
6 Additionally, after treatment of cell lines with DHT, protein levels of TGF-beta1 receptors (TGFBR1-TGFBR2) showed a decrease (p < 0.05) that might cause a potential disorder in TGF-beta1 response, represented by the significant decrease in p21 protein levels in the presence of DHT (p < 0.001). Dihydrotestosterone transforming growth factor beta 1 Homo sapiens