Pub. Date : 2015 Jun 18
PMID : 26086967
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | APR-246 is a prodrug that is converted to the active compound methylene quinuclidinone (MQ), a Michael acceptor that binds to cysteine residues in mutant p53 and restores its wild-type conformation. | Cysteine | tumor protein p53 | Homo sapiens |
| 2 | We propose that this unique ability of APR-246/MQ to bind to cysteines in both mutant p53 and glutathione has a key role in the resensitization as well as in the outstanding synergistic effects observed with APR-246 in combination with platinum compounds in ovarian cancer cell lines and primary cancer cells. | Cysteine | tumor protein p53 | Homo sapiens |