Title : Cell proliferation and drug sensitivity of human glioblastoma cells are altered by the stable modulation of cytosolic 5'-nucleotidase II.

Pub. Date : 2015 Aug

PMID : 26079827






2 Functional Relationships(s)
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1 Finally, we observed sensitivity to cisplatin in cN-II silenced cells and resistance to this same drug in cN-II over-expressing cells indicating an involvement of cN-II in the mechanism of action of platinum derivatives, and most probably in DNA repair. Platinum 5'-nucleotidase, cytosolic II Homo sapiens
2 Finally, we observed sensitivity to cisplatin in cN-II silenced cells and resistance to this same drug in cN-II over-expressing cells indicating an involvement of cN-II in the mechanism of action of platinum derivatives, and most probably in DNA repair. Platinum 5'-nucleotidase, cytosolic II Homo sapiens