Title : Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment.

Pub. Date : 2015

PMID : 26070072






1 Functional Relationships(s)
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1 Computational modeling suggested that a p53 tetramer containing two wild-type p53 molecules and two C176F mutated molecules can maintain the structural stability and interactions with DNA by formation of additional hydrophobic and cation-pi interactions which compensate for the loss of sulphur-zinc coordination. Sulfur tumor protein p53 Homo sapiens