Title : Inhibition kinetics of acetylcholinesterase with fluoromethyl ketones.

Pub. Date : 1989 Oct 17

PMID : 2605196






2 Functional Relationships(s)
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1 The compound (5,5,5-trifluoro-4-oxopentyl)trimethylammonium bicarbonate (1) inhibits acetylcholinesterase with Ki = 0.06 X 10(-9)M and pseudocholinesterase with Ki = 70 X 10(-9)M. Replacement of the nitrogen of 1 by carbon (compound 2) increases Ki for 1 200-fold for acetylcholinesterase but does not significantly alter Ki for pseudocholinesterase. 5,5,5-trifluoro-4-oxopentyl)trimethylammonium bicarbonate acetylcholinesterase (Cartwright blood group) Homo sapiens
2 The compound (5,5,5-trifluoro-4-oxopentyl)trimethylammonium bicarbonate (1) inhibits acetylcholinesterase with Ki = 0.06 X 10(-9)M and pseudocholinesterase with Ki = 70 X 10(-9)M. Replacement of the nitrogen of 1 by carbon (compound 2) increases Ki for 1 200-fold for acetylcholinesterase but does not significantly alter Ki for pseudocholinesterase. 5,5,5-trifluoro-4-oxopentyl)trimethylammonium bicarbonate acetylcholinesterase (Cartwright blood group) Homo sapiens