Title : Time-dependent changes in inhibitory action of lipopolysaccharide on intestinal motility in rat.

Pub. Date : 2015 Nov

PMID : 26051129






2 Functional Relationships(s)
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1 All subtypes of prostaglandin E2 (PGE2) receptors (EP1-EP4) were expressed in ileum, and PGE2 and selective EP2 or EP4 agonist inhibited CCh-mediated contraction. Dinoprostone prostaglandin E receptor 2 Rattus norvegicus
2 In conclusion, LPS induces COX-2 to produce PGE2, which initially activates EP2 and/or EP4 on smooth muscle cells to inhibit the contractility in early phase of LPS exposure. Dinoprostone prostaglandin E receptor 2 Rattus norvegicus