Title : AMP-activated protein kinase is activated by non-steroidal anti-inflammatory drugs.

Pub. Date : 2015 Sep 5

PMID : 26049010






1 Functional Relationships(s)
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1 Our results showed that the non-selective acidic NSAIDs ibuprofen and diclofenac induced AMPK activation similar to aspirin while the COX-2 selective drug etoricoxib and the non-opioid analgesic paracetamol, both drugs have no acidic structure, failed to activate AMPK. Etoricoxib cytochrome c oxidase II, mitochondrial Mus musculus