Title : Sodium nitrite causes relaxation of the isolated rat aorta: By stimulating both endothelial NO synthase and activating soluble guanylyl cyclase in vascular smooth muscle.

Pub. Date : 2015 Nov

PMID : 26044183






2 Functional Relationships(s)
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1 The presence of NO scavengers decreased the relaxation to nitrite in both WKY and SHR preparations while inhibition of soluble guanylyl cyclase (sGC) abolished the response, indicating that besides producing NO, nitrite also induces relaxation by directly activating the enzyme. Nitrites guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus
2 The presence of NO scavengers decreased the relaxation to nitrite in both WKY and SHR preparations while inhibition of soluble guanylyl cyclase (sGC) abolished the response, indicating that besides producing NO, nitrite also induces relaxation by directly activating the enzyme. Nitrites guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus